Cousins, Bo and Luke Duke, with the help of their eye-catching cousin, Daisy and moonshine-running Uncle Jesse, try and save the family farm from being destroyed by Hazzard County's corrupt commissioner, Boss Hogg. Their efforts constantly find the 'Duke Boys' eluding authorities in 'The General Lee', their 1969 orange Dodge Charger that keeps them one step ahead of the dimwitted antics of the small southern town's Sheriff, Roscoe P. Coltrane.
Cousins Bo, Luke and Daisy are sent to Hazzard County, Georgia for the first time to live with their Uncle Jesse. Jesse is a farmer and a moonshiner and is constantly battling his old rival Boss Hogg who is the corrupt city commissioner of the small town.
The Duke Boys and company travel to Hollywood to sell some musical recordings in order to raise money to build a new hospital in Hazzard County. However, when their recordings and money are stolen, they wind up on the run from mysterious hitmen, sleazy record producers, Russian gangsters, and vicious loan sharks.
Mama Josephine Max wants to build a theme park in Hazzard, right on the Duke family farm! To stop her, Bo and Luke have to win a cross-country moonshine race. Because that's how things get settled in Hazzard.
Cousins Bo and Luke Duke and their car "General Lee", assisted by Cousin Daisy and Uncle Jesse, have a running battle with the authorities of Hazzard County (Boss Hogg and Sheriff Coltrane), plus a string of ne'er-do-wells often backed by the scheming Hogg.